Dopamine beta-hydroxylase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-15Dopamine beta-hydroxylase shows clinical signal disease relevance led by pulmonary arterial hypertension. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P09172. Start with pulmonary arterial hypertension, then reuse UniProt P09172 as the stable protein anchor across project notes and exports.
Start with pulmonary arterial hypertension, then reuse UniProt P09172 as the stable protein anchor across project notes and exports.
Dopamine beta-hydroxylase shows clinical signal disease relevance led by pulmonary arterial hypertension. 1 linked drug remains visible in the same block.
Start review with pulmonary arterial hypertension because it currently carries clinical signal support. Linked drugs include ZAMICASTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyDopamine beta-hydroxylase
Review this target as Dopamine beta-hydroxylase, mapped to UniProt P09172. Sequence length is 617 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dopamine beta-hydroxylase as ChEMBL target CHEMBL3102, mapped to UniProt P09172. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Dopamine beta-hydroxylase is the right protein anchor across sources, using UniProt P09172 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why pulmonary arterial hypertension is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Dopamine beta-hydroxylase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P09172 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dopamine beta-hydroxylase |
| UniProt Accession | P09172 |
| Component Type | Protein |
| Sequence Length | 617 aa |
Dopamine beta-hydroxylase
Review this target as Dopamine beta-hydroxylase, mapped to UniProt P09172. Sequence length is 617 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Dopamine beta-hydroxylase shows clinical signal disease relevance led by pulmonary arterial hypertension.
Start review with pulmonary arterial hypertension because it currently carries clinical signal support. Linked drugs include ZAMICASTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL433493 | 7.13 | IC50 | 74.13 | Preclinical |
| CHEMBL63990 | 6.17 | IC50 | 676.08 | Preclinical |
| CHEMBL278068 | 5.92 | IC50 | 1202.26 | Preclinical |
| CHEMBL64937 | 5.82 | IC50 | 1513.56 | Preclinical |
| CHEMBL121188 | 5.7 | IC50 | 2000.0 | Preclinical |
| CHEMBL3357560 | 5.7 | IC50 | 2000.0 | Preclinical |
| CHEMBL67235 | 5.7 | IC50 | 1995.26 | Preclinical |
| CHEMBL3752910 | 5.66 | Kd | 2177.48 | Preclinical |
| CHEMBL67369 | 5.66 | IC50 | 2187.76 | Preclinical |
| CHEMBL293669 | 5.62 | IC50 | 2398.83 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 6 | 56 | 4.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |