Transcription intermediary factor 1-alpha · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt O15164. Use UniProt O15164 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O15164 as the stable identity anchor, then attach disease evidence before program review.
Transcription intermediary factor 1-alpha
Review this target as Transcription intermediary factor 1-alpha, mapped to UniProt O15164. Sequence length is 1050 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Transcription intermediary factor 1-alpha as ChEMBL target CHEMBL3108638, mapped to UniProt O15164. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Transcription intermediary factor 1-alpha |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O15164 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Transcription intermediary factor 1-alpha |
| UniProt Accession | O15164 |
| Component Type | Protein |
| Sequence Length | 1050 aa |
Transcription intermediary factor 1-alpha
Review this target as Transcription intermediary factor 1-alpha, mapped to UniProt O15164. Sequence length is 1050 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3774575 | 8.89 | Kd | 1.3 | Preclinical |
| CHEMBL3774575 | 8.12 | IC50 | 7.6 | Preclinical |
| CHEMBL5715923 | 8.12 | IC50 | 7.6 | Preclinical |
| CHEMBL3775251 | 8.1 | IC50 | 7.9 | Preclinical |
| CHEMBL3774933 | 8.08 | IC50 | 8.3 | Preclinical |
| CHEMBL3775901 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL3775348 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL3774542 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL3774766 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL5715923 | 7.51 | Kd | 31.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 58 | 166 | 5.4 |
| assay format | 32 | 10 | 5.6 |
| cell-based format | 17 | 60 | 6.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 8.1 |
| cell-based format | 1 | 1 | 7.3 |