Histone-lysine N-methyltransferase NSD2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O96028. Use UniProt O96028 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O96028 as the stable identity anchor, then attach disease evidence before program review.
Histone-lysine N-methyltransferase NSD2
Review this target as Histone-lysine N-methyltransferase NSD2, mapped to UniProt O96028. Sequence length is 1365 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histone-lysine N-methyltransferase NSD2 as ChEMBL target CHEMBL3108645, mapped to UniProt O96028. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Histone-lysine N-methyltransferase NSD2 is the right protein anchor across sources, using UniProt O96028 as the stable mapping.
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| Preferred Name | Histone-lysine N-methyltransferase NSD2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O96028 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histone-lysine N-methyltransferase NSD2 |
| UniProt Accession | O96028 |
| Component Type | Protein |
| Sequence Length | 1365 aa |
Histone-lysine N-methyltransferase NSD2
Review this target as Histone-lysine N-methyltransferase NSD2, mapped to UniProt O96028. Sequence length is 1365 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5557662 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5200945 | 8.91 | IC50 | 1.23 | Preclinical |
| CHEMBL5559507 | 8.6 | Kd | 2.512 | Preclinical |
| CHEMBL5559507 | 8.4 | IC50 | 3.981 | Preclinical |
| CHEMBL5396709 | 8.26 | IC50 | 5.5 | Preclinical |
| CHEMBL5408212 | 8.26 | IC50 | 5.5 | Preclinical |
| CHEMBL5419719 | 8.26 | IC50 | 5.5 | Preclinical |
| CHEMBL5422710 | 8.26 | IC50 | 5.5 | Preclinical |
| CHEMBL5425629 | 8.26 | IC50 | 5.5 | Preclinical |
| CHEMBL5432302 | 8.26 | IC50 | 5.5 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 102 | 149 | 6.1 |
| cell-based format | 72 | 46 | 6.7 |
| assay format | 22 | 376 | 6.6 |
| biochemical format | 1 | 0 | — |