Histone-lysine N-methyltransferase NSD3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9BZ95. Use UniProt Q9BZ95 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9BZ95 as the stable identity anchor, then attach disease evidence before program review.
Histone-lysine N-methyltransferase NSD3
Review this target as Histone-lysine N-methyltransferase NSD3, mapped to UniProt Q9BZ95. Sequence length is 1437 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histone-lysine N-methyltransferase NSD3 as ChEMBL target CHEMBL3108646, mapped to UniProt Q9BZ95. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Histone-lysine N-methyltransferase NSD3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9BZ95 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histone-lysine N-methyltransferase NSD3 |
| UniProt Accession | Q9BZ95 |
| Component Type | Protein |
| Sequence Length | 1437 aa |
Histone-lysine N-methyltransferase NSD3
Review this target as Histone-lysine N-methyltransferase NSD3, mapped to UniProt Q9BZ95. Sequence length is 1437 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5396709 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5408212 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5419719 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5425629 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5432302 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5433029 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5438312 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL1232461 | 7.52 | Kd | 30.0 | Clinical |
| CHEMBL5416709 | 7.34 | Kd | 46.0 | Preclinical |
| CHEMBL4758943 | 7.04 | Kd | 91.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 72 | 20 | 5.7 |
| cell-based format | 46 | 10 | 7.8 |
| assay format | 16 | 32 | 5.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 0 | — |