ATP-dependent 6-phosphofructokinase · SINGLE PROTEIN · Trypanosoma cruzi
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As of 2026-09-14Protein identity stays anchored to UniProt Q4E657. Use UniProt Q4E657 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q4E657 as the stable identity anchor, then attach disease evidence before program review.
ATP-dependent 6-phosphofructokinase
Review this target as ATP-dependent 6-phosphofructokinase, mapped to UniProt Q4E657. Sequence length is 485 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats ATP-dependent 6-phosphofructokinase as ChEMBL target CHEMBL3108659, mapped to UniProt Q4E657. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether ATP-dependent 6-phosphofructokinase is the right protein anchor across sources, using UniProt Q4E657 as the stable mapping.
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| Preferred Name | ATP-dependent 6-phosphofructokinase |
| Target Type | SINGLE PROTEIN |
| Organism | Trypanosoma cruzi |
| UniProt | Q4E657 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | ATP-dependent 6-phosphofructokinase |
| UniProt Accession | Q4E657 |
| Component Type | Protein |
| Sequence Length | 485 aa |
ATP-dependent 6-phosphofructokinase
Review this target as ATP-dependent 6-phosphofructokinase, mapped to UniProt Q4E657. Sequence length is 485 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3108867 | 7.39 | IC50 | 41.0 | Preclinical |
| CHEMBL3108869 | 7.28 | IC50 | 52.0 | Preclinical |
| CHEMBL3108868 | 6.92 | IC50 | 120.0 | Preclinical |
| CHEMBL3108858 | 6.89 | IC50 | 130.0 | Preclinical |
| CHEMBL3108870 | 6.76 | IC50 | 172.0 | Preclinical |
| CHEMBL1394402 | 6.64 | IC50 | 230.0 | Preclinical |
| CHEMBL3108863 | 6.54 | IC50 | 290.0 | Preclinical |
| CHEMBL3108848 | 6.34 | IC50 | 460.0 | Preclinical |
| CHEMBL3108856 | 6.34 | IC50 | 460.0 | Preclinical |
| CHEMBL3108861 | 6.24 | IC50 | 580.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 37 | 5.7 |