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Target Snapshot

CHEMBL3111 Target Snapshot

Ribosomal protein S6 kinase beta-2 · SINGLE PROTEIN · Homo sapiens

115Compounds
79Assays
0Approved Drugs
25.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9UBS0. Use UniProt Q9UBS0 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9UBS0 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Ribosomal protein S6 kinase beta-2 as ChEMBL target CHEMBL3111, mapped to UniProt Q9UBS0. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Ribosomal protein S6 kinase beta-2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3111
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9UBS0
Ribosomal protein S6 kinase beta-2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Ribosomal protein S6 kinase beta-2 is the right protein anchor across sources, using UniProt Q9UBS0 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelRibosomal protein S6 kinase beta-2
UniProt AccessionQ9UBS0
Component TypeProtein
Sequence Length482 aa

Ribosomal protein S6 kinase beta-2

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Ribosomal protein S6 kinase beta-2, mapped to UniProt Q9UBS0. Sequence length is 482 aa.

Mapped IDQ9UBS0
Review nameRibosomal protein S6 kinase beta-2
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5025.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL388978 9.14 IC50 0.726 Preclinical
CHEMBL5570033 8.35 IC50 4.48 Preclinical
CHEMBL5571683 7.74 IC50 18.2 Preclinical
CHEMBL426445 7.4 IC50 40.0 Preclinical
CHEMBL192909 6.19 IC50 640.0 Preclinical
CHEMBL190057 6.09 IC50 820.0 Preclinical
CHEMBL366201 6.06 IC50 870.0 Preclinical
CHEMBL193232 6.02 IC50 950.0 Preclinical
CHEMBL193172 5.94 IC50 1140.0 Preclinical
CHEMBL193162 5.89 IC50 1280.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
4
5.5
4
6.0
0
6.5
1
7.0
1
7.5
1
8.0
2
8.5
1
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

79
Total Assays
19
Tested Compounds
1
Assay Types
Binding — 79 assays, 19 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 54 18 6.3
cell-based format 12 1 5.8
subcellular format 12 0
assay format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine