Use UniProt Q9UBS0 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL3111 Target Snapshot
Ribosomal protein S6 kinase beta-2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9UBS0. Use UniProt Q9UBS0 as the stable identity anchor, then attach disease evidence before program review.
Ribosomal protein S6 kinase beta-2
Review this target as Ribosomal protein S6 kinase beta-2, mapped to UniProt Q9UBS0. Sequence length is 482 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Ribosomal protein S6 kinase beta-2 as ChEMBL target CHEMBL3111, mapped to UniProt Q9UBS0. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Ribosomal protein S6 kinase beta-2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9UBS0 |
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UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Ribosomal protein S6 kinase beta-2 |
| UniProt Accession | Q9UBS0 |
| Component Type | Protein |
| Sequence Length | 482 aa |
Ribosomal protein S6 kinase beta-2
How to read this target
Review this target as Ribosomal protein S6 kinase beta-2, mapped to UniProt Q9UBS0. Sequence length is 482 aa.
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 9.14 | IC50 | 0.726 | Preclinical |
| CHEMBL5570033 | 8.35 | IC50 | 4.48 | Preclinical |
| CHEMBL5571683 | 7.74 | IC50 | 18.2 | Preclinical |
| CHEMBL426445 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL192909 | 6.19 | IC50 | 640.0 | Preclinical |
| CHEMBL190057 | 6.09 | IC50 | 820.0 | Preclinical |
| CHEMBL366201 | 6.06 | IC50 | 870.0 | Preclinical |
| CHEMBL193232 | 6.02 | IC50 | 950.0 | Preclinical |
| CHEMBL193172 | 5.94 | IC50 | 1140.0 | Preclinical |
| CHEMBL193162 | 5.89 | IC50 | 1280.0 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 79 assays, 19 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 54 | 18 | 6.3 |
| cell-based format | 12 | 1 | 5.8 |
| subcellular format | 12 | 0 | — |
| assay format | 1 | 0 | — |