Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL3112375 Target Snapshot

Protein-lysine 6-oxidase · SINGLE PROTEIN · Sus scrofa

105Compounds
2Assays
0Approved Drugs
108.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P45845. Use UniProt P45845 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P45845 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Protein-lysine 6-oxidase as ChEMBL target CHEMBL3112375, mapped to UniProt P45845. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Protein-lysine 6-oxidase
SINGLE PROTEIN · Sus scrofa
As of 2026-09-14
ChEMBL target ID
CHEMBL3112375
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P45845
Protein-lysine 6-oxidase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Protein-lysine 6-oxidase is the right protein anchor across sources, using UniProt P45845 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProtein-lysine 6-oxidase
UniProt AccessionP45845
Component TypeProtein
Sequence Length249 aa

Protein-lysine 6-oxidase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Protein-lysine 6-oxidase, mapped to UniProt P45845. Sequence length is 249 aa.

Mapped IDP45845
Review nameProtein-lysine 6-oxidase
OrganismSus scrofa
Assay Mix

Activity Type Distribution

IC50108.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4596739 6.52 IC50 300.0 Preclinical
CHEMBL4458145 6.47 IC50 340.0 Preclinical
CHEMBL4596503 6.4 IC50 400.0 Preclinical
CHEMBL4536193 6.38 IC50 420.0 Preclinical
CHEMBL4596022 6.36 IC50 440.0 Preclinical
CHEMBL4596599 6.35 IC50 450.0 Preclinical
CHEMBL4597756 6.35 IC50 450.0 Preclinical
CHEMBL4595977 6.33 IC50 470.0 Preclinical
CHEMBL4535726 6.32 IC50 480.0 Preclinical
CHEMBL4453938 6.29 IC50 510.0 Preclinical
Distribution

pChEMBL Value Distribution

12
5.0
48
5.5
27
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
88
Tested Compounds
1
Assay Types
Binding — 2 assays, 88 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 88 5.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine