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Target Snapshot

CHEMBL3112378 Target Snapshot

Proteasome subunit beta type-2 · SINGLE PROTEIN · Mus musculus

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16Compounds
2Assays
0Approved Drugs
12.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9R1P3. Use UniProt Q9R1P3 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9R1P3 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Proteasome subunit beta type-2 as ChEMBL target CHEMBL3112378, mapped to UniProt Q9R1P3. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Proteasome subunit beta type-2
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL3112378
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9R1P3
Proteasome subunit beta type-2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Proteasome subunit beta type-2 is the right protein anchor across sources, using UniProt Q9R1P3 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameProteasome subunit beta type-2
Target TypeSINGLE PROTEIN
OrganismMus musculus
UniProtQ9R1P3
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProteasome subunit beta type-2
UniProt AccessionQ9R1P3
Component TypeProtein
Sequence Length201 aa

Proteasome subunit beta type-2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Proteasome subunit beta type-2, mapped to UniProt Q9R1P3. Sequence length is 201 aa.

Mapped IDQ9R1P3
Review nameProteasome subunit beta type-2
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Phase II
Assay Mix

Activity Type Distribution

IC5012.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4465456 6.85 IC50 141.0 Preclinical
CHEMBL4452892 6.24 IC50 573.0 Preclinical
CHEMBL4297468 6.07 IC50 857.0 Clinical
CHEMBL3237875 6.04 IC50 913.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
3
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
4
Tested Compounds
1
Assay Types
Binding — 2 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 4 6.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine