Choline kinase alpha · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Choline kinase alpha shows clinical signal disease relevance led by neoplasm. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P35790. Start with neoplasm, then reuse UniProt P35790 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt P35790 as the stable protein anchor across project notes and exports.
Choline kinase alpha shows clinical signal disease relevance led by neoplasm. 1 linked drug remains visible in the same block.
Start review with neoplasm because it currently carries clinical signal support. Linked drugs include RSM-932A. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyCholine kinase alpha
Review this target as Choline kinase alpha, mapped to UniProt P35790. Sequence length is 457 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Choline kinase alpha as ChEMBL target CHEMBL3117, mapped to UniProt P35790. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Choline kinase alpha is the right protein anchor across sources, using UniProt P35790 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Choline kinase alpha |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P35790 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Choline kinase alpha |
| UniProt Accession | P35790 |
| Component Type | Protein |
| Sequence Length | 457 aa |
Choline kinase alpha
Review this target as Choline kinase alpha, mapped to UniProt P35790. Sequence length is 457 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Choline kinase alpha shows clinical signal disease relevance led by neoplasm.
Start review with neoplasm because it currently carries clinical signal support. Linked drugs include RSM-932A. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3763540 | 8.0 | Kd | 10.0 | Preclinical |
| CHEMBL5091519 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL5094847 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL3765554 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL5078600 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL5079663 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL3764278 | 7.68 | Kd | 21.0 | Preclinical |
| CHEMBL5090932 | 7.68 | IC50 | 21.0 | Preclinical |
| CHEMBL5077194 | 7.66 | IC50 | 22.0 | Preclinical |
| CHEMBL5075042 | 7.64 | IC50 | 23.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 30 | 215 | 5.8 |
| cell-based format | 10 | 10 | 5.4 |
| subcellular format | 4 | 0 | — |
| assay format | 1 | 0 | — |