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Target Snapshot

CHEMBL3119 Target Snapshot

Transient receptor potential cation channel subfamily V member 4 · SINGLE PROTEIN · Homo sapiens

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763Compounds
95Assays
0Approved Drugs
844.0Activities
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Broader Open DB context

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Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Transient receptor potential cation channel subfamily V member 4 shows clinical signal disease relevance led by congestive heart failure. 4 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q9HBA0. Start with congestive heart failure, then reuse UniProt Q9HBA0 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with congestive heart failure, then reuse UniProt Q9HBA0 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
congestive heart failure

Transient receptor potential cation channel subfamily V member 4 shows clinical signal disease relevance led by congestive heart failure. 4 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with congestive heart failure because it currently carries clinical signal support. Linked drugs include GSK2798745. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Clinical signal Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Transient receptor potential cation channel subfamily V member 4 as ChEMBL target CHEMBL3119, mapped to UniProt Q9HBA0. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Transient receptor potential cation channel subfamily V member 4
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3119
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9HBA0
Transient receptor potential cation channel subfamily V member 4
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Transient receptor potential cation channel subfamily V member 4 is the right protein anchor across sources, using UniProt Q9HBA0 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why congestive heart failure is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
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Overview

Basic Information

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Preferred NameTransient receptor potential cation channel subfamily V member 4
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9HBA0
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTransient receptor potential cation channel subfamily V member 4
UniProt AccessionQ9HBA0
Component TypeProtein
Sequence Length871 aa

Transient receptor potential cation channel subfamily V member 4

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Transient receptor potential cation channel subfamily V member 4, mapped to UniProt Q9HBA0. Sequence length is 871 aa.

Mapped IDQ9HBA0
Review nameTransient receptor potential cation channel subfamily V member 4
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Clinical signal Open Targets-ready proxy

Transient receptor potential cation channel subfamily V member 4 shows clinical signal disease relevance led by congestive heart failure. 4 more disease programs remain visible in the same review block.

Clinical signal Phase II
congestive heart failure
1 linked drug · 1 direct · 1 efficacy
Linked drugGSK2798745
Clinical signal Phase II
heart failure
1 linked drug · 1 direct · 1 efficacy
Linked drugGSK2798745
Clinical signal Phase II
pulmonary edema
1 linked drug · 1 direct · 1 efficacy
Linked drugGSK2798745
Clinical signal Phase I
Cough
1 linked drug · 1 direct · 1 efficacy
Linked drugGSK2798745
Clinical signal Phase I
macular retinal edema
1 linked drug · 1 direct · 1 efficacy
Linked drugGSK2798745
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with congestive heart failure because it currently carries clinical signal support. Linked drugs include GSK2798745. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasecongestive heart failure
Strongest levelClinical signal
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

2
Phase III
7
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50688.0
KI122.0
EC5034.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4096902 9.74 IC50 0.18 Preclinical
CHEMBL4101768 9.72 IC50 0.19 Preclinical
CHEMBL4066531 9.68 IC50 0.21 Preclinical
CHEMBL3941914 9.66 IC50 0.22 Preclinical
CHEMBL4099293 9.54 IC50 0.29 Preclinical
CHEMBL3971502 9.52 IC50 0.3 Preclinical
CHEMBL4456312 9.52 IC50 0.3 Preclinical
CHEMBL4077638 9.51 IC50 0.31 Preclinical
CHEMBL3984947 9.44 IC50 0.36 Preclinical
CHEMBL4078117 9.41 IC50 0.39 Preclinical
Distribution

pChEMBL Value Distribution

74
5.0
128
5.5
112
6.0
69
6.5
165
7.0
39
7.5
81
8.0
34
8.5
20
9.0
10
9.5
pChEMBL
Assay Landscape

Assay Landscape

95
Total Assays
625
Tested Compounds
2
Assay Types
Binding — 90 assays, 625 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 62 562 6.8
single protein format 27 63 7.3
assay format 1 0 —
Functional — 5 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 5 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine