Polyunsaturated fatty acid 5-lipoxygenase · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P12527. Use UniProt P12527 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P12527 as the stable identity anchor, then attach disease evidence before program review.
Polyunsaturated fatty acid 5-lipoxygenase
Review this target as Polyunsaturated fatty acid 5-lipoxygenase, mapped to UniProt P12527. Sequence length is 673 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Polyunsaturated fatty acid 5-lipoxygenase as ChEMBL target CHEMBL312, mapped to UniProt P12527. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Polyunsaturated fatty acid 5-lipoxygenase |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P12527 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Polyunsaturated fatty acid 5-lipoxygenase |
| UniProt Accession | P12527 |
| Component Type | Protein |
| Sequence Length | 673 aa |
Polyunsaturated fatty acid 5-lipoxygenase
Review this target as Polyunsaturated fatty acid 5-lipoxygenase, mapped to UniProt P12527. Sequence length is 673 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL126838 | 8.62 | IC50 | 2.4 | Preclinical |
| CHEMBL125415 | 8.42 | IC50 | 3.8 | Preclinical |
| CHEMBL129590 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL341135 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL126669 | 8.38 | IC50 | 4.2 | Preclinical |
| CHEMBL2115381 | 8.37 | IC50 | 4.3 | Preclinical |
| CHEMBL128000 | 8.34 | IC50 | 4.6 | Preclinical |
| CHEMBL262892 | 8.33 | IC50 | 4.7 | Preclinical |
| CHEMBL114516 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL29097 | 8.3 | IC50 | 5.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 164 | 998 | 5.9 |
| single protein format | 51 | 241 | 5.8 |
| assay format | 38 | 191 | 6.2 |
| organism-based format | 4 | 7 | 6.6 |
| tissue-based format | 3 | 5 | 5.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 20 | 100 | 5.5 |
| cell-based format | 19 | 175 | 5.9 |
| organism-based format | 4 | 0 | — |
| tissue-based format | 3 | 14 | 6.3 |