Ribosomal protein S6 kinase alpha-4 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt O75676. Use UniProt O75676 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O75676 as the stable identity anchor, then attach disease evidence before program review.
Ribosomal protein S6 kinase alpha-4
Review this target as Ribosomal protein S6 kinase alpha-4, mapped to UniProt O75676. Sequence length is 772 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Ribosomal protein S6 kinase alpha-4 as ChEMBL target CHEMBL3125, mapped to UniProt O75676. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Ribosomal protein S6 kinase alpha-4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O75676 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Ribosomal protein S6 kinase alpha-4 |
| UniProt Accession | O75676 |
| Component Type | Protein |
| Sequence Length | 772 aa |
Ribosomal protein S6 kinase alpha-4
Review this target as Ribosomal protein S6 kinase alpha-4, mapped to UniProt O75676. Sequence length is 772 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 8.74 | IC50 | 1.82 | Preclinical |
| CHEMBL3752910 | 8.06 | Kd | 8.766 | Preclinical |
| CHEMBL495727 | 8.0 | IC50 | 10.0 | Clinical |
| CHEMBL513909 | 7.92 | Kd | 12.0 | Clinical |
| CHEMBL5184056 | 7.7 | IC50 | 19.95 | Preclinical |
| CHEMBL1987679 | 7.7 | Ki | 19.95 | Preclinical |
| CHEMBL603469 | 7.55 | Kd | 28.0 | Clinical |
| CHEMBL2002726 | 7.4 | Ki | 39.81 | Preclinical |
| CHEMBL475251 | 7.36 | Kd | 44.0 | Clinical |
| CHEMBL223360 | 7.3 | Ki | 50.12 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 260 | 42 | 6.3 |
| assay format | 49 | 0 | — |
| cell-based format | 26 | 6 | 6.2 |
| subcellular format | 16 | 21 | 6.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 18 | 6.8 |