Guanine deaminase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9Y2T3. Use UniProt Q9Y2T3 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9Y2T3 as the stable identity anchor, then attach disease evidence before program review.
Guanine deaminase
Review this target as Guanine deaminase, mapped to UniProt Q9Y2T3. Sequence length is 454 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Guanine deaminase as ChEMBL target CHEMBL3129, mapped to UniProt Q9Y2T3. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Guanine deaminase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y2T3 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Guanine deaminase |
| UniProt Accession | Q9Y2T3 |
| Component Type | Protein |
| Sequence Length | 454 aa |
Guanine deaminase
Review this target as Guanine deaminase, mapped to UniProt Q9Y2T3. Sequence length is 454 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388596 | 5.73 | Ki | 1880.0 | Preclinical |
| CHEMBL1424 | 5.71 | Ki | 1960.0 | Preclinical |
| CHEMBL1224659 | 5.46 | Ki | 3440.0 | Preclinical |
| CHEMBL792 | 5.36 | Ki | 4340.0 | Clinical |
| CHEMBL1610 | 5.35 | Ki | 4440.0 | Preclinical |
| CHEMBL2203870 | 5.3 | IC50 | 5000.0 | Preclinical |
| CHEMBL321248 | 5.26 | Ki | 5550.0 | Clinical |
| CHEMBL113 | 5.0 | Ki | 10000.0 | Approved |
| CHEMBL1645489 | 4.78 | Ki | 16700.0 | Preclinical |
| CHEMBL374469 | 4.7 | Ki | 20100.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 7 | 9 | 5.3 |
| assay format | 3 | 4 | 4.5 |