Nicotinic acetylcholine receptor alpha1/beta1/epsilon/delta · PROTEIN COMPLEX · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt P04756. Use UniProt P04756 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P04756 as the stable identity anchor, then attach disease evidence before program review.
Acetylcholine receptor subunit alpha
Review this target as Nicotinic acetylcholine receptor alpha1/beta1/epsilon/delta, mapped to UniProt P04756. ChEMBL maps the protein component as Acetylcholine receptor subunit alpha. Sequence length is 457 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Nicotinic acetylcholine receptor alpha1/beta1/epsilon/delta as ChEMBL target CHEMBL3137264, mapped to UniProt P04756. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Nicotinic acetylcholine receptor alpha1/beta1/epsilon/delta is the right protein anchor across sources, using UniProt P04756 as the stable mapping.
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| Preferred Name | Nicotinic acetylcholine receptor alpha1/beta1/epsilon/delta |
| Target Type | PROTEIN COMPLEX |
| Organism | Mus musculus |
| UniProt | P04756 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Acetylcholine receptor subunit alpha |
| UniProt Accession | P04756 |
| Component Type | Protein |
| Sequence Length | 457 aa |
Acetylcholine receptor subunit alpha
Review this target as Nicotinic acetylcholine receptor alpha1/beta1/epsilon/delta, mapped to UniProt P04756. ChEMBL maps the protein component as Acetylcholine receptor subunit alpha. Sequence length is 457 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5439154 | 6.43 | IC50 | 370.0 | Preclinical |
| CHEMBL5417971 | 6.33 | IC50 | 470.0 | Preclinical |
| CHEMBL4460879 | 6.28 | IC50 | 520.0 | Preclinical |
| CHEMBL5435613 | 6.28 | IC50 | 520.0 | Preclinical |
| CHEMBL5431759 | 6.21 | IC50 | 610.0 | Preclinical |
| CHEMBL5400807 | 6.19 | IC50 | 640.0 | Preclinical |
| CHEMBL5414842 | 6.19 | IC50 | 650.0 | Preclinical |
| CHEMBL5427601 | 6.15 | IC50 | 710.0 | Preclinical |
| CHEMBL5419995 | 6.11 | IC50 | 770.0 | Preclinical |
| CHEMBL5440747 | 6.1 | IC50 | 800.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 11 | 48 | 5.9 |
| assay format | 1 | 0 | — |