P2X2/P2X3 receptor · PROTEIN COMPLEX · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P49653. Use UniProt P49653 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P49653 as the stable identity anchor, then attach disease evidence before program review.
P2X purinoceptor 2
Review this target as P2X2/P2X3 receptor, mapped to UniProt P49653. ChEMBL maps the protein component as P2X purinoceptor 2. Sequence length is 472 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats P2X2/P2X3 receptor as ChEMBL target CHEMBL3137277, mapped to UniProt P49653. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether P2X2/P2X3 receptor is the right protein anchor across sources, using UniProt P49653 as the stable mapping.
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| Preferred Name | P2X2/P2X3 receptor |
| Target Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
| UniProt | P49653 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | P2X purinoceptor 2 |
| UniProt Accession | P49653 |
| Component Type | Protein |
| Sequence Length | 472 aa |
P2X purinoceptor 2
Review this target as P2X2/P2X3 receptor, mapped to UniProt P49653. ChEMBL maps the protein component as P2X purinoceptor 2. Sequence length is 472 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2324342 | 7.13 | IC50 | 74.0 | Preclinical |
| CHEMBL5562824 | 6.26 | IC50 | 547.2 | Preclinical |
| CHEMBL1672104 | 5.98 | IC50 | 1042.0 | Preclinical |
| CHEMBL2011125 | 5.07 | IC50 | 8580.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 2 | 6.1 |
| protein complex format | 1 | 1 | 6.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 6.0 |
| cell-based format | 1 | 0 | — |