Nicotinic acetylcholine receptor alpha6/alpha3/beta4 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P30926. Use UniProt P30926 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P30926 as the stable identity anchor, then attach disease evidence before program review.
Neuronal acetylcholine receptor subunit beta-4
Review this target as Nicotinic acetylcholine receptor alpha6/alpha3/beta4, mapped to UniProt P30926. ChEMBL maps the protein component as Neuronal acetylcholine receptor subunit beta-4. Sequence length is 498 aa.
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This review treats Nicotinic acetylcholine receptor alpha6/alpha3/beta4 as ChEMBL target CHEMBL3137285, mapped to UniProt P30926. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Nicotinic acetylcholine receptor alpha6/alpha3/beta4 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P30926 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neuronal acetylcholine receptor subunit beta-4 |
| UniProt Accession | P30926 |
| Component Type | Protein |
| Sequence Length | 498 aa |
Neuronal acetylcholine receptor subunit beta-4
Review this target as Nicotinic acetylcholine receptor alpha6/alpha3/beta4, mapped to UniProt P30926. ChEMBL maps the protein component as Neuronal acetylcholine receptor subunit beta-4. Sequence length is 498 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4869892 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL4860756 | 9.62 | IC50 | 0.24 | Preclinical |
| CHEMBL4876825 | 9.55 | IC50 | 0.28 | Preclinical |
| CHEMBL4878931 | 9.39 | IC50 | 0.41 | Preclinical |
| CHEMBL4872474 | 8.84 | IC50 | 1.46 | Preclinical |
| CHEMBL4468892 | 8.83 | IC50 | 1.49 | Preclinical |
| CHEMBL5087554 | 8.82 | IC50 | 1.5 | Preclinical |
| CHEMBL4462168 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL4439678 | 8.66 | IC50 | 2.2 | Preclinical |
| CHEMBL4878856 | 8.65 | IC50 | 2.24 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 11 | 55 | 7.6 |
| protein complex format | 1 | 1 | 7.9 |