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Target Snapshot

CHEMBL3137287 Target Snapshot

EZH1/SUZ12/EED/AEBP2/RBBP4 complex · PROTEIN COMPLEX · Homo sapiens

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29Compounds
3Assays
1Approved Drugs
28.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q92800. Use UniProt Q92800 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q92800 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats EZH1/SUZ12/EED/AEBP2/RBBP4 complex as ChEMBL target CHEMBL3137287, mapped to UniProt Q92800. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
EZH1/SUZ12/EED/AEBP2/RBBP4 complex
PROTEIN COMPLEX · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3137287
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q92800
Histone-lysine N-methyltransferase EZH1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether EZH1/SUZ12/EED/AEBP2/RBBP4 complex is the right protein anchor across sources, using UniProt Q92800 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameEZH1/SUZ12/EED/AEBP2/RBBP4 complex
Target TypePROTEIN COMPLEX
OrganismHomo sapiens
UniProtQ92800
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHistone-lysine N-methyltransferase EZH1
UniProt AccessionQ92800
Component TypeProtein
Sequence Length747 aa

Histone-lysine N-methyltransferase EZH1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as EZH1/SUZ12/EED/AEBP2/RBBP4 complex, mapped to UniProt Q92800. ChEMBL maps the protein component as Histone-lysine N-methyltransferase EZH1. Sequence length is 747 aa.

Mapped IDQ92800
Review nameEZH1/SUZ12/EED/AEBP2/RBBP4 complex
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5028.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4159112 10.0 IC50 0.1 Preclinical
CHEMBL4161265 9.4 IC50 0.4 Preclinical
CHEMBL4165937 9.3 IC50 0.5 Preclinical
CHEMBL4160111 9.22 IC50 0.6 Preclinical
CHEMBL4172576 9.1 IC50 0.8 Preclinical
CHEMBL4164687 8.57 IC50 2.7 Preclinical
CHEMBL4170327 8.54 IC50 2.9 Preclinical
CHEMBL4162316 8.48 IC50 3.3 Preclinical
CHEMBL4177454 8.42 IC50 3.8 Preclinical
CHEMBL3414621 8.4 IC50 4.0 Approved
Distribution

pChEMBL Value Distribution

0
5.0
2
5.5
1
6.0
1
6.5
1
7.0
1
7.5
15
8.0
2
8.5
4
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TAZEMETOSTAT
CHEMBL3414621
Approved 2020
Properties Compare Identifier
Assay Landscape

Assay Landscape

3
Total Assays
28
Tested Compounds
1
Assay Types
Binding — 3 assays, 28 compounds
BAO Format Assays Compounds Avg pChEMBL
protein complex format 2 3 6.4
cell-based format 1 25 8.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine