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Target Snapshot

CHEMBL3140324 Target Snapshot

Hepatocyte · CELL-LINE · Mus musculus

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569Compounds
333Assays
0Approved Drugs
142.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Hepatocyte as ChEMBL target CHEMBL3140324. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Hepatocyte
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL3140324
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Hepatocyte still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHepatocyte
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHepatocyte
UniProt AccessionN/A

Hepatocyte

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Hepatocyte.

Review nameHepatocyte
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

2
Phase III
3
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50109.0
EC5033.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1688236 8.1 EC50 8.0 Preclinical
CHEMBL1688231 7.89 EC50 13.0 Preclinical
CHEMBL1688234 7.77 EC50 17.0 Preclinical
CHEMBL3734797 7.26 EC50 55.0 Preclinical
CHEMBL233611 6.52 EC50 300.0 Preclinical
CHEMBL4161115 5.77 IC50 1700.0 Preclinical
CHEMBL257943 5.58 IC50 2600.0 Preclinical
CHEMBL1778556 5.57 EC50 2700.0 Preclinical
CHEMBL1778555 5.4 EC50 4000.0 Preclinical
CHEMBL444478 5.34 IC50 4600.0 Clinical
Distribution

pChEMBL Value Distribution

22
5.0
4
5.5
0
6.0
1
6.5
1
7.0
2
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

333
Total Assays
109
Tested Compounds
3
Assay Types
ADME — 160 assays, 9 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 160 9 4.3
Functional — 158 assays, 109 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 156 94 4.8
organism-based format 2 15 5.2
Toxicity — 15 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 15 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine