Review anchor
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
Evidence Snapshot
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
CHEMBL3145
SINGLE PROTEIN
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform as ChEMBL target CHEMBL3145, mapped to UniProt P42338. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL3145
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P42338
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform matters
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform is reviewed as Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (UniProt P42338); Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform shows clinical signal disease relevance led by lymphoma. 5 more disease programs remain visible in the same review block.; 1 linked drug keep this evidence frame grounded.; the current evidence base includes 8 approved drugs, 4425 compounds, and 686 assays, with lead potency reaching pChEMBL 10.7.
Protein context
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Sequence length is 1070 aa.
Review this target as Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, mapped to UniProt P42338. Sequence length is 1070 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P42338
Protein
Disease context
lymphoma
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform shows clinical signal disease relevance led by lymphoma. 5 more disease programs remain visible in the same review block. 1 linked drug keep the rationale reviewable. 5 additional disease programs remain visible in the same card. Linked drugs include FIMEPINOSTAT.
Start review with lymphoma because it currently carries clinical signal support. Linked drugs include FIMEPINOSTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target record
Clinical signal
1 linked drug
Activity base
Portfolio and assay base
ChEMBL currently tracks 8 approved drugs, 4425 compounds, and 686 assays for this target. The dominant activity type is IC50. CHEMBL1236962 is the current potency anchor at pChEMBL 10.7.
Use CHEMBL1236962 as the tractability anchor when discussing potency (pChEMBL 10.7).
Activity source · ChEMBL 36 via Core Engine
8 approved
pChEMBL 10.7
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P42338, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need to see why lymphoma is currently treated as clinical signal support.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
4425
Total Compounds
686
Total Assays
8
Approved Drugs
IC50: 4876.0, KI: 204.0, EC50: 120.0, KD: 150.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL1236962
|
10.7 | Ki | Clinical |
|
|
No preferred name
CHEMBL2089119
|
10.3 | IC50 | — |
|
|
No preferred name
CHEMBL4127116
|
10.0 | Kd | — |
|
|
No preferred name
CHEMBL2089114
|
10.0 | IC50 | — |
|
|
No preferred name
CHEMBL1236962
|
9.9 | IC50 | Clinical |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
INAVOLISIB
CHEMBL4650215
|
2024 |
|
|
LENIOLISIB
CHEMBL3643413
|
2023 |
|
|
ALPELISIB
CHEMBL2396661
|
2019 |
|
|
DUVELISIB
CHEMBL3039502
|
2018 |
|
|
COPANLISIB
CHEMBL3218576
|
2017 |
|
|
COPANLISIB HYDROCHLORIDE
CHEMBL3545068
|
2017 |
|
|
IDELALISIB
CHEMBL2216870
|
2014 |
Source Header