Alpha-1B adrenergic receptor · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P15823. Use UniProt P15823 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P15823 as the stable identity anchor, then attach disease evidence before program review.
Alpha-1B adrenergic receptor
Review this target as Alpha-1B adrenergic receptor, mapped to UniProt P15823. Sequence length is 515 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Alpha-1B adrenergic receptor as ChEMBL target CHEMBL315, mapped to UniProt P15823. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Alpha-1B adrenergic receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P15823 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Alpha-1B adrenergic receptor |
| UniProt Accession | P15823 |
| Component Type | Protein |
| Sequence Length | 515 aa |
Alpha-1B adrenergic receptor
Review this target as Alpha-1B adrenergic receptor, mapped to UniProt P15823. Sequence length is 515 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1259128 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL2 | 10.0 | Ki | 0.099 | Approved |
| CHEMBL27013 | 9.84 | Kd | 0.1445 | Preclinical |
| CHEMBL1259216 | 9.82 | Ki | 0.15 | Preclinical |
| CHEMBL1259129 | 9.82 | Ki | 0.15 | Preclinical |
| CHEMBL2 | 9.75 | IC50 | 0.178 | Approved |
| CHEMBL1558 | 9.72 | IC50 | 0.19 | Approved |
| CHEMBL836 | 9.69 | Kd | 0.2042 | Approved |
| CHEMBL217469 | 9.69 | Kd | 0.2042 | Preclinical |
| CHEMBL2261604 | 9.68 | Ki | 0.2089 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 31 | 41 | 6.7 |
| assay format | 14 | 27 | 7.8 |
| tissue-based format | 14 | 14 | 7.6 |
| cell membrane format | 9 | 110 | 7.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 34 | 72 | 7.8 |
| assay format | 5 | 20 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 1 | 7.0 |