Neuromedin-K receptor · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P16177. Use UniProt P16177 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P16177 as the stable identity anchor, then attach disease evidence before program review.
Neuromedin-K receptor
Review this target as Neuromedin-K receptor, mapped to UniProt P16177. Sequence length is 452 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neuromedin-K receptor as ChEMBL target CHEMBL3154, mapped to UniProt P16177. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Neuromedin-K receptor is the right protein anchor across sources, using UniProt P16177 as the stable mapping.
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| Preferred Name | Neuromedin-K receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P16177 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neuromedin-K receptor |
| UniProt Accession | P16177 |
| Component Type | Protein |
| Sequence Length | 452 aa |
Neuromedin-K receptor
Review this target as Neuromedin-K receptor, mapped to UniProt P16177. Sequence length is 452 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3734811 | 10.89 | EC50 | 0.013 | Preclinical |
| CHEMBL106124 | 10.64 | EC50 | 0.023 | Preclinical |
| CHEMBL305119 | 8.3 | Ki | 5.0 | Preclinical |
| CHEMBL65468 | 8.26 | Ki | 5.5 | Preclinical |
| CHEMBL437797 | 8.2 | EC50 | 6.3 | Preclinical |
| CHEMBL106124 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL3422009 | 7.9 | Ki | 12.59 | Preclinical |
| CHEMBL3361404 | 7.72 | EC50 | 19.0 | Preclinical |
| CHEMBL3422018 | 7.7 | Ki | 19.95 | Preclinical |
| CHEMBL45340 | 7.52 | IC50 | 30.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 14 | 35 | 5.6 |
| cell-based format | 2 | 5 | 9.0 |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 7 | 20 | 6.9 |
| assay format | 4 | 8 | 6.8 |
| cell membrane format | 1 | 0 | — |
| cell-based format | 1 | 4 | 7.1 |
| subcellular format | 1 | 21 | 5.9 |