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Target Snapshot

CHEMBL318 Target Snapshot

Adenosine receptor A1 · SINGLE PROTEIN · Rattus norvegicus

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3,770Compounds
644Assays
10Approved Drugs
4,798.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P25099. Use UniProt P25099 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P25099 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Adenosine receptor A1 as ChEMBL target CHEMBL318, mapped to UniProt P25099. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Adenosine receptor A1
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL318
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P25099
Adenosine receptor A1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Adenosine receptor A1 is the right protein anchor across sources, using UniProt P25099 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameAdenosine receptor A1
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtP25099
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAdenosine receptor A1
UniProt AccessionP25099
Component TypeProtein
Sequence Length326 aa

Adenosine receptor A1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Adenosine receptor A1, mapped to UniProt P25099. Sequence length is 326 aa.

Mapped IDP25099
Review nameAdenosine receptor A1
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

10
Approved
12
Phase III
12
Phase II
3
Phase I
1
Phase 0.5
Assay Mix

Activity Type Distribution

IC50470.0
KI4,138.0
EC50147.0
KD43.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4796077 10.2 Ki 0.0628 Preclinical
CHEMBL4796077 10.17 IC50 0.067 Preclinical
CHEMBL4797181 10.15 Ki 0.0709 Preclinical
CHEMBL4797181 10.12 IC50 0.0756 Preclinical
CHEMBL4764086 10.06 Ki 0.0867 Preclinical
CHEMBL4764086 10.03 IC50 0.0929 Preclinical
CHEMBL1316674 9.91 Ki 0.124 Preclinical
CHEMBL3093327 9.91 Ki 0.124 Preclinical
CHEMBL216269 9.9 Kd 0.1259 Preclinical
CHEMBL414157 9.8 Kd 0.1585 Clinical
Distribution

pChEMBL Value Distribution

432
5.0
488
5.5
592
6.0
559
6.5
537
7.0
364
7.5
322
8.0
161
8.5
138
9.0
24
9.5
pChEMBL
Approved Drugs

Approved Drugs

ISTRADEFYLLINE
CHEMBL431770
Approved 2013
Properties Compare Identifier
ADENOSINE
CHEMBL477
Approved 1989
Properties Compare Identifier
THEOPHYLLINE
CHEMBL1355736
Approved 1976
Properties Compare Identifier
Assay Landscape

Assay Landscape

644
Total Assays
3,274
Tested Compounds
2
Assay Types
Binding — 593 assays, 3,274 compounds
BAO Format Assays Compounds Avg pChEMBL
cell membrane format 258 1,304 6.4
assay format 136 880 6.6
single protein format 107 399 7.1
tissue-based format 64 567 6.7
cell-based format 28 124 6.5
Functional — 51 assays, 124 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 21 48 6.6
cell membrane format 19 74 6.8
cell-based format 6 2 8.5
tissue-based format 3 0 —
organism-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine