Cocaine esterase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O00748. Use UniProt O00748 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O00748 as the stable identity anchor, then attach disease evidence before program review.
Cocaine esterase
Review this target as Cocaine esterase, mapped to UniProt O00748. Sequence length is 559 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cocaine esterase as ChEMBL target CHEMBL3180, mapped to UniProt O00748. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Cocaine esterase is the right protein anchor across sources, using UniProt O00748 as the stable mapping.
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| Preferred Name | Cocaine esterase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O00748 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cocaine esterase |
| UniProt Accession | O00748 |
| Component Type | Protein |
| Sequence Length | 559 aa |
Cocaine esterase
Review this target as Cocaine esterase, mapped to UniProt O00748. Sequence length is 559 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL155514 | 9.75 | IC50 | 0.1778 | Preclinical |
| CHEMBL193140 | 8.49 | Ki | 3.2 | Preclinical |
| CHEMBL155513 | 8.47 | IC50 | 3.388 | Preclinical |
| CHEMBL4854298 | 8.39 | IC50 | 4.04 | Preclinical |
| CHEMBL191847 | 8.36 | Ki | 4.4 | Preclinical |
| CHEMBL4853742 | 8.36 | IC50 | 4.33 | Preclinical |
| CHEMBL395018 | 8.3 | Ki | 4.98 | Preclinical |
| CHEMBL153080 | 8.26 | IC50 | 5.495 | Preclinical |
| CHEMBL362996 | 8.25 | Ki | 5.6 | Preclinical |
| CHEMBL5593400 | 8.25 | Ki | 5.6 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 30 | 136 | 6.7 |
| microsome format | 12 | 84 | 5.6 |
| cell-based format | 10 | 34 | 6.8 |
| tissue-based format | 4 | 15 | 5.4 |
| assay format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 29 | 3 | 6.1 |
| cell-based format | 15 | 0 | — |
| assay format | 7 | 0 | — |
| tissue-based format | 5 | 0 | — |