Muscarinic acetylcholine receptor M2 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt Q9ERZ4. Use UniProt Q9ERZ4 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9ERZ4 as the stable identity anchor, then attach disease evidence before program review.
Muscarinic acetylcholine receptor M2
Review this target as Muscarinic acetylcholine receptor M2, mapped to UniProt Q9ERZ4. Sequence length is 466 aa.
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This review treats Muscarinic acetylcholine receptor M2 as ChEMBL target CHEMBL3197, mapped to UniProt Q9ERZ4. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Muscarinic acetylcholine receptor M2 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | Q9ERZ4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Muscarinic acetylcholine receptor M2 |
| UniProt Accession | Q9ERZ4 |
| Component Type | Protein |
| Sequence Length | 466 aa |
Muscarinic acetylcholine receptor M2
Review this target as Muscarinic acetylcholine receptor M2, mapped to UniProt Q9ERZ4. Sequence length is 466 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL517712 | 9.46 | Ki | 0.35 | Approved |
| CHEMBL7634 | 8.77 | Ki | 1.7 | Preclinical |
| CHEMBL14 | 8.1 | Ki | 8.0 | Approved |
| CHEMBL95 | 6.66 | Ki | 220.0 | Approved |
| CHEMBL418712 | 6.4 | IC50 | 400.0 | Preclinical |
| CHEMBL107892 | 6.34 | Ki | 460.0 | Preclinical |
| CHEMBL12858 | 6.33 | IC50 | 470.0 | Preclinical |
| CHEMBL13206 | 6.3 | IC50 | 500.0 | Preclinical |
| CHEMBL13166 | 6.28 | IC50 | 520.0 | Preclinical |
| CHEMBL418714 | 6.27 | IC50 | 540.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 0 | — |
| tissue-based format | 6 | 21 | 6.3 |
| single protein format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 2 | 0 | — |