Acetylcholinesterase · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt P21836. Use UniProt P21836 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P21836 as the stable identity anchor, then attach disease evidence before program review.
Acetylcholinesterase
Review this target as Acetylcholinesterase, mapped to UniProt P21836. Sequence length is 614 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Acetylcholinesterase as ChEMBL target CHEMBL3198, mapped to UniProt P21836. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Acetylcholinesterase |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P21836 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Acetylcholinesterase |
| UniProt Accession | P21836 |
| Component Type | Protein |
| Sequence Length | 614 aa |
Acetylcholinesterase
Review this target as Acetylcholinesterase, mapped to UniProt P21836. Sequence length is 614 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL56960 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL517712 | 9.46 | Ki | 0.35 | Approved |
| CHEMBL5180947 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL117651 | 9.39 | Ki | 0.41 | Preclinical |
| CHEMBL542744 | 9.25 | IC50 | 0.56 | Preclinical |
| CHEMBL299708 | 9.22 | IC50 | 0.5998 | Preclinical |
| CHEMBL54058 | 9.22 | IC50 | 0.5998 | Preclinical |
| CHEMBL2007996 | 9.21 | IC50 | 0.62 | Preclinical |
| CHEMBL94 | 9.17 | IC50 | 0.68 | Clinical |
| CHEMBL5082250 | 8.94 | Ki | 1.16 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 45 | 243 | 6.2 |
| assay format | 33 | 162 | 6.1 |
| tissue-based format | 22 | 198 | 7.0 |
| organism-based format | 7 | 3 | 6.9 |
| cell-based format | 5 | 3 | 6.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 17 | 7 | 6.8 |
| tissue-based format | 10 | 0 | — |
| assay format | 9 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 1 | 6.9 |