Muscarinic acetylcholine receptor M3 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P08483. Use UniProt P08483 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P08483 as the stable identity anchor, then attach disease evidence before program review.
Muscarinic acetylcholine receptor M3
Review this target as Muscarinic acetylcholine receptor M3, mapped to UniProt P08483. Sequence length is 589 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Muscarinic acetylcholine receptor M3 as ChEMBL target CHEMBL320, mapped to UniProt P08483. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Muscarinic acetylcholine receptor M3 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P08483 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Muscarinic acetylcholine receptor M3 |
| UniProt Accession | P08483 |
| Component Type | Protein |
| Sequence Length | 589 aa |
Muscarinic acetylcholine receptor M3
Review this target as Muscarinic acetylcholine receptor M3, mapped to UniProt P08483. Sequence length is 589 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3298595 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL3298599 | 10.31 | Ki | 0.049 | Preclinical |
| CHEMBL376897 | 10.3 | EC50 | 0.05 | Approved |
| CHEMBL3298588 | 10.25 | Ki | 0.056 | Preclinical |
| CHEMBL3298596 | 10.19 | Ki | 0.064 | Preclinical |
| CHEMBL320611 | 10.01 | Ki | 0.0986 | Preclinical |
| CHEMBL3298600 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL3298763 | 9.92 | Ki | 0.12 | Preclinical |
| CHEMBL517712 | 9.92 | Ki | 0.12 | Approved |
| CHEMBL3298333 | 9.92 | Ki | 0.12 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 53 | 41 | 6.0 |
| single protein format | 40 | 94 | 7.3 |
| tissue-based format | 12 | 51 | 7.3 |
| assay format | 11 | 59 | 6.0 |
| cell membrane format | 3 | 4 | 5.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 58 | 9 | 6.6 |
| assay format | 3 | 2 | 8.1 |
| single protein format | 2 | 0 | — |
| tissue-based format | 2 | 8 | 8.2 |