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Target Snapshot

CHEMBL3202 Target Snapshot

Prolyl endopeptidase · SINGLE PROTEIN · Homo sapiens

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848Compounds
197Assays
0Approved Drugs
962.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P48147. Use UniProt P48147 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P48147 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Prolyl endopeptidase as ChEMBL target CHEMBL3202, mapped to UniProt P48147. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Prolyl endopeptidase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3202
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P48147
Prolyl endopeptidase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Prolyl endopeptidase is the right protein anchor across sources, using UniProt P48147 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameProlyl endopeptidase
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP48147
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProlyl endopeptidase
UniProt AccessionP48147
Component TypeProtein
Sequence Length710 aa

Prolyl endopeptidase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Prolyl endopeptidase, mapped to UniProt P48147. Sequence length is 710 aa.

Mapped IDP48147
Review nameProlyl endopeptidase
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC50821.0
KI139.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL189620 10.7 Ki 0.02 Preclinical
CHEMBL6058811 9.8 IC50 0.16 Preclinical
CHEMBL5813416 9.77 IC50 0.17 Preclinical
CHEMBL5874048 9.7 IC50 0.2 Preclinical
CHEMBL97152 9.68 Ki 0.21 Preclinical
CHEMBL6052358 9.66 IC50 0.22 Preclinical
CHEMBL95698 9.59 Ki 0.26 Preclinical
CHEMBL318284 9.55 Ki 0.28 Preclinical
CHEMBL5941199 9.49 IC50 0.325 Preclinical
CHEMBL318630 9.47 Ki 0.34 Preclinical
Distribution

pChEMBL Value Distribution

74
5.0
67
5.5
94
6.0
52
6.5
70
7.0
59
7.5
48
8.0
32
8.5
32
9.0
7
9.5
pChEMBL
Assay Landscape

Assay Landscape

197
Total Assays
558
Tested Compounds
2
Assay Types
Binding — 195 assays, 558 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 143 342 6.5
cell-based format 34 30 6.3
assay format 18 186 6.2
Functional — 2 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 1 7.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine