Matrix metalloproteinase-9 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Matrix metalloproteinase-9 shows late clinical disease relevance led by breast cancer. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P14780. Start with breast cancer, then reuse UniProt P14780 as the stable protein anchor across project notes and exports.
Start with breast cancer, then reuse UniProt P14780 as the stable protein anchor across project notes and exports.
Matrix metalloproteinase-9 shows late clinical disease relevance led by breast cancer. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with breast cancer because it currently carries late clinical support. Linked drugs include MARIMASTAT, REBIMASTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMatrix metalloproteinase-9
Review this target as Matrix metalloproteinase-9, mapped to UniProt P14780. Sequence length is 707 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Matrix metalloproteinase-9 as ChEMBL target CHEMBL321, mapped to UniProt P14780. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Matrix metalloproteinase-9 is the right protein anchor across sources, using UniProt P14780 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why breast cancer is currently framed as late clinical support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Matrix metalloproteinase-9 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P14780 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Matrix metalloproteinase-9 |
| UniProt Accession | P14780 |
| Component Type | Protein |
| Sequence Length | 707 aa |
Matrix metalloproteinase-9
Review this target as Matrix metalloproteinase-9, mapped to UniProt P14780. Sequence length is 707 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Matrix metalloproteinase-9 shows late clinical disease relevance led by breast cancer. 5 more disease programs remain visible in the same review block.
Start review with breast cancer because it currently carries late clinical support. Linked drugs include MARIMASTAT, REBIMASTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL323090 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL2064547 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL75094 | 10.52 | Ki | 0.03 | Clinical |
| CHEMBL75094 | 10.32 | IC50 | 0.048 | Clinical |
| CHEMBL19611 | 10.3 | IC50 | 0.05 | Clinical |
| CHEMBL2064549 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL2064548 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL61193 | 10.22 | Ki | 0.06 | Preclinical |
| CHEMBL2425941 | 10.15 | IC50 | 0.07 | Preclinical |
| CHEMBL2425947 | 10.15 | IC50 | 0.07 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 545 | 2,658 | 7.1 |
| cell-based format | 89 | 140 | 5.6 |
| assay format | 19 | 43 | 5.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 17 | 13 | 6.4 |
| cell-based format | 2 | 1 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 0 | — |
| assay format | 1 | 0 | — |
| organism-based format | 1 | 0 | — |