2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase · SINGLE PROTEIN · Escherichia coli (strain K12)
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As of 2026-09-14Protein identity stays anchored to UniProt P26281. Use UniProt P26281 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P26281 as the stable identity anchor, then attach disease evidence before program review.
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Review this target as 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, mapped to UniProt P26281. Sequence length is 159 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase as ChEMBL target CHEMBL3217379, mapped to UniProt P26281. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase |
| Target Type | SINGLE PROTEIN |
| Organism | Escherichia coli (strain K12) |
| UniProt | P26281 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase |
| UniProt Accession | P26281 |
| Component Type | Protein |
| Sequence Length | 159 aa |
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Review this target as 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, mapped to UniProt P26281. Sequence length is 159 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1928286 | 6.36 | IC50 | 440.0 | Preclinical |
| CHEMBL1928286 | 6.33 | Kd | 470.0 | Preclinical |
| CHEMBL3818894 | 6.16 | Kd | 700.0 | Preclinical |
| CHEMBL3819161 | 6.02 | Kd | 950.0 | Preclinical |
| CHEMBL3818561 | 6.01 | Kd | 965.0 | Preclinical |
| CHEMBL3233217 | 5.98 | Kd | 1050.0 | Preclinical |
| CHEMBL3818521 | 5.85 | Kd | 1400.0 | Preclinical |
| CHEMBL3818783 | 5.77 | Kd | 1700.0 | Preclinical |
| CHEMBL3819246 | 5.77 | Kd | 1700.0 | Preclinical |
| CHEMBL3817872 | 5.75 | Kd | 1760.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 7 | 59 | 5.0 |
| single protein format | 6 | 3 | 5.7 |