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Target Snapshot

CHEMBL3217397 Target Snapshot

C-C chemokine receptor type 5 · SINGLE PROTEIN · Macaca mulatta

19Compounds
6Assays
1Approved Drugs
18.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P61813. Use UniProt P61813 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P61813 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats C-C chemokine receptor type 5 as ChEMBL target CHEMBL3217397, mapped to UniProt P61813. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
C-C chemokine receptor type 5
SINGLE PROTEIN · Macaca mulatta
As of 2026-09-14
ChEMBL target ID
CHEMBL3217397
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P61813
C-C chemokine receptor type 5
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether C-C chemokine receptor type 5 is the right protein anchor across sources, using UniProt P61813 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelC-C chemokine receptor type 5
UniProt AccessionP61813
Component TypeProtein
Sequence Length352 aa

C-C chemokine receptor type 5

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as C-C chemokine receptor type 5, mapped to UniProt P61813. Sequence length is 352 aa.

Mapped IDP61813
Review nameC-C chemokine receptor type 5
OrganismMacaca mulatta
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

KI18.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL256907 9.62 Ki 0.24 Approved
CHEMBL5071060 8.62 Ki 2.39 Preclinical
CHEMBL5074744 8.48 Ki 3.29 Preclinical
CHEMBL5089300 8.24 Ki 5.7 Preclinical
CHEMBL3219780 7.82 Ki 15.3 Preclinical
CHEMBL5094690 7.39 Ki 41.0 Preclinical
CHEMBL3219779 6.82 Ki 151.0 Preclinical
CHEMBL4795179 6.82 Ki 151.0 Preclinical
CHEMBL3219777 6.62 Ki 239.0 Preclinical
CHEMBL4748891 6.62 Ki 239.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
4
6.5
1
7.0
1
7.5
2
8.0
1
8.5
0
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

MARAVIROC
CHEMBL256907
Approved 2007
Assay Landscape

Assay Landscape

6
Total Assays
11
Tested Compounds
2
Assay Types
Binding — 4 assays, 11 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 8 8.0
cell membrane format 1 3 7.7
Functional — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine