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Evidence Snapshot

5-hydroxytryptamine receptor 7

CHEMBL3223 SINGLE PROTEIN Rattus norvegicus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T21:24:43Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3223
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 5-hydroxytryptamine receptor 7 as ChEMBL target CHEMBL3223, mapped to UniProt P32305. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
5-hydroxytryptamine receptor 7
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL3223
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P32305
5-hydroxytryptamine receptor 7
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why 5-hydroxytryptamine receptor 7 matters

As of 2026-09-13

5-hydroxytryptamine receptor 7 is reviewed as 5-hydroxytryptamine receptor 7 (UniProt P32305); the current evidence base includes 13 approved drugs, 848 compounds, and 107 assays, with lead potency reaching pChEMBL 10.5.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 13 approved drugs, 848 compounds, and 107 assays for this target. The dominant activity type is KI. CHEMBL18840 is the current potency anchor at pChEMBL 10.5.

Use CHEMBL18840 as the tractability anchor when discussing potency (pChEMBL 10.5).

Activity source · ChEMBL 36 via Core Engine
13 approved pChEMBL 10.5
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why 5-hydroxytryptamine receptor 7 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P32305, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

848
Total Compounds
107
Total Assays
13
Approved Drugs
IC50: 2.0, KI: 969.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL18840
 10.5 Ki —
No preferred name
CHEMBL243954
 9.9 Ki —
No preferred name
CHEMBL225284
 9.7 Ki —
No preferred name
CHEMBL611472
 9.6 Ki —
No preferred name
CHEMBL1423
 9.3 Ki Approved

Approved Drugs

Structure Compound First Approval
ARIPIPRAZOLE
CHEMBL1112
 2002
APOMORPHINE
CHEMBL53
 2001
RISPERIDONE
CHEMBL85
 1993
CLOZAPINE
CHEMBL42
 1989
PIMOZIDE
CHEMBL1423
 1984
LOXAPINE
CHEMBL831
 1975
CHLORPROTHIXENE
CHEMBL908
 1967
HALOPERIDOL
CHEMBL54
 1967
METHYSERGIDE
CHEMBL1065
 1962
CYPROHEPTADINE
CHEMBL516
 1961
CHLORPROMAZINE
CHEMBL71
 1957
MIANSERIN
CHEMBL6437
 —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T21:24:43Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3223