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Target Snapshot

CHEMBL3227916 Target Snapshot

Thymidine kinase, cytosolic · SINGLE PROTEIN · Cricetulus griseus

53Compounds
38Assays
0Approved Drugs
28.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P09768. Use UniProt P09768 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P09768 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Thymidine kinase, cytosolic as ChEMBL target CHEMBL3227916, mapped to UniProt P09768. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Thymidine kinase, cytosolic
SINGLE PROTEIN · Cricetulus griseus
As of 2026-09-14
ChEMBL target ID
CHEMBL3227916
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P09768
Thymidine kinase, cytosolic
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Thymidine kinase, cytosolic is the right protein anchor across sources, using UniProt P09768 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelThymidine kinase, cytosolic
UniProt AccessionP09768
Component TypeProtein
Sequence Length234 aa

Thymidine kinase, cytosolic

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Thymidine kinase, cytosolic, mapped to UniProt P09768. Sequence length is 234 aa.

Mapped IDP09768
Review nameThymidine kinase, cytosolic
OrganismCricetulus griseus
Assay Mix

Activity Type Distribution

IC506.0
KI22.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3229812 4.92 Ki 12000.0 Preclinical
CHEMBL3229794 4.19 Ki 65000.0 Preclinical
CHEMBL3143490 4.14 Ki 72000.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

38
Total Assays
25
Tested Compounds
1
Assay Types
Binding — 38 assays, 25 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 38 25 4.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine