Fatty-acid amide hydrolase 1 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P97612. Use UniProt P97612 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P97612 as the stable identity anchor, then attach disease evidence before program review.
Fatty-acid amide hydrolase 1
Review this target as Fatty-acid amide hydrolase 1, mapped to UniProt P97612. Sequence length is 579 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Fatty-acid amide hydrolase 1 as ChEMBL target CHEMBL3229, mapped to UniProt P97612. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Fatty-acid amide hydrolase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P97612 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Fatty-acid amide hydrolase 1 |
| UniProt Accession | P97612 |
| Component Type | Protein |
| Sequence Length | 579 aa |
Fatty-acid amide hydrolase 1
Review this target as Fatty-acid amide hydrolase 1, mapped to UniProt P97612. Sequence length is 579 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL367966 | 10.55 | Ki | 0.028 | Preclinical |
| CHEMBL477372 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL3318616 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL4070196 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL175580 | 9.85 | Ki | 0.14 | Preclinical |
| CHEMBL3318605 | 9.8 | Ki | 0.16 | Preclinical |
| CHEMBL3318613 | 9.8 | Ki | 0.16 | Preclinical |
| CHEMBL3113272 | 9.77 | IC50 | 0.17 | Preclinical |
| CHEMBL3318617 | 9.72 | Ki | 0.19 | Preclinical |
| CHEMBL175854 | 9.7 | Ki | 0.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 126 | 855 | 7.2 |
| tissue-based format | 68 | 297 | 6.4 |
| single protein format | 66 | 541 | 6.9 |
| cell membrane format | 40 | 229 | 6.5 |
| cell-based format | 26 | 99 | 7.4 |
| microsome format | 11 | 154 | 7.0 |
| subcellular format | 5 | 1 | 7.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 24 | 0 | — |
| assay format | 2 | 0 | — |
| cell membrane format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 0 | — |
| tissue-based format | 2 | 0 | — |