Sphingosine 1-phosphate receptor 4 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Sphingosine 1-phosphate receptor 4 shows approved-linked disease relevance led by ulcerative colitis. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt O95977. Start with ulcerative colitis, then reuse UniProt O95977 as the stable protein anchor across project notes and exports.
Start with ulcerative colitis, then reuse UniProt O95977 as the stable protein anchor across project notes and exports.
Sphingosine 1-phosphate receptor 4 shows approved-linked disease relevance led by ulcerative colitis. 1 linked drug remains visible in the same block.
Start review with ulcerative colitis because it currently carries approved-linked support. Linked drugs include ETRASIMOD ARGININE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxySphingosine 1-phosphate receptor 4
Review this target as Sphingosine 1-phosphate receptor 4, mapped to UniProt O95977. Sequence length is 384 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sphingosine 1-phosphate receptor 4 as ChEMBL target CHEMBL3230, mapped to UniProt O95977. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Sphingosine 1-phosphate receptor 4 is the right protein anchor across sources, using UniProt O95977 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why ulcerative colitis is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | Sphingosine 1-phosphate receptor 4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O95977 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sphingosine 1-phosphate receptor 4 |
| UniProt Accession | O95977 |
| Component Type | Protein |
| Sequence Length | 384 aa |
Sphingosine 1-phosphate receptor 4
Review this target as Sphingosine 1-phosphate receptor 4, mapped to UniProt O95977. Sequence length is 384 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Sphingosine 1-phosphate receptor 4 shows approved-linked disease relevance led by ulcerative colitis.
Start review with ulcerative colitis because it currently carries approved-linked support. Linked drugs include ETRASIMOD ARGININE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL114606 | 10.05 | EC50 | 0.09 | Preclinical |
| CHEMBL314854 | 9.52 | EC50 | 0.3 | Approved |
| CHEMBL4458575 | 9.3 | EC50 | 0.5 | Preclinical |
| CHEMBL366208 | 9.22 | EC50 | 0.6 | Preclinical |
| CHEMBL190006 | 9.15 | EC50 | 0.7 | Preclinical |
| CHEMBL4448752 | 9.04 | EC50 | 0.92 | Preclinical |
| CHEMBL225155 | 8.98 | IC50 | 1.04 | Preclinical |
| CHEMBL474689 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL470511 | 8.91 | IC50 | 1.23 | Preclinical |
| CHEMBL382739 | 8.9 | EC50 | 1.259 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 60 | 292 | 6.2 |
| assay format | 12 | 15 | 7.3 |
| cell membrane format | 2 | 6 | 8.3 |
| single protein format | 1 | 2 | 9.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 29 | 156 | 6.5 |
| single protein format | 27 | 124 | 5.3 |
| assay format | 1 | 1 | 6.8 |