Tyrosine-protein phosphatase non-receptor type 12 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q05209. Use UniProt Q05209 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q05209 as the stable identity anchor, then attach disease evidence before program review.
Tyrosine-protein phosphatase non-receptor type 12
Review this target as Tyrosine-protein phosphatase non-receptor type 12, mapped to UniProt Q05209. Sequence length is 780 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tyrosine-protein phosphatase non-receptor type 12 as ChEMBL target CHEMBL3236, mapped to UniProt Q05209. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Tyrosine-protein phosphatase non-receptor type 12 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q05209 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein phosphatase non-receptor type 12 |
| UniProt Accession | Q05209 |
| Component Type | Protein |
| Sequence Length | 780 aa |
Tyrosine-protein phosphatase non-receptor type 12
Review this target as Tyrosine-protein phosphatase non-receptor type 12, mapped to UniProt Q05209. Sequence length is 780 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4750435 | 6.89 | IC50 | 130.0 | Preclinical |
| CHEMBL1408081 | 6.67 | IC50 | 216.0 | Preclinical |
| CHEMBL1407368 | 6.5 | IC50 | 313.0 | Preclinical |
| CHEMBL1701224 | 6.49 | IC50 | 325.0 | Preclinical |
| CHEMBL1320181 | 6.33 | IC50 | 471.0 | Preclinical |
| CHEMBL1390354 | 6.15 | IC50 | 714.0 | Preclinical |
| CHEMBL2396718 | 6.1 | IC50 | 800.0 | Preclinical |
| CHEMBL1572439 | 6.04 | IC50 | 916.0 | Preclinical |
| CHEMBL1704862 | 6.02 | IC50 | 953.0 | Preclinical |
| CHEMBL601167 | 6.01 | IC50 | 975.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 9 | 13 | 5.2 |
| assay format | 2 | 10 | 4.6 |
| cell-based format | 2 | 9 | 4.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 3 | 1 | 5.5 |
| assay format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 64 | 5.2 |