5-hydroxytryptamine receptor 2C · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P08909. Use UniProt P08909 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P08909 as the stable identity anchor, then attach disease evidence before program review.
5-hydroxytryptamine receptor 2C
Review this target as 5-hydroxytryptamine receptor 2C, mapped to UniProt P08909. Sequence length is 460 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 5-hydroxytryptamine receptor 2C as ChEMBL target CHEMBL324, mapped to UniProt P08909. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 5-hydroxytryptamine receptor 2C |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P08909 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 2C |
| UniProt Accession | P08909 |
| Component Type | Protein |
| Sequence Length | 460 aa |
5-hydroxytryptamine receptor 2C
Review this target as 5-hydroxytryptamine receptor 2C, mapped to UniProt P08909. Sequence length is 460 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL6706 | 9.96 | Ki | 0.11 | Preclinical |
| CHEMBL3764539 | 9.81 | Ki | 0.156 | Preclinical |
| CHEMBL111184 | 9.8 | Ki | 0.16 | Preclinical |
| CHEMBL14563 | 9.8 | Ki | 0.16 | Preclinical |
| CHEMBL324270 | 9.68 | Ki | 0.21 | Preclinical |
| CHEMBL263083 | 9.6 | Ki | 0.25 | Preclinical |
| CHEMBL6710 | 9.59 | Ki | 0.26 | Preclinical |
| CHEMBL12314 | 9.43 | Ki | 0.37 | Clinical |
| CHEMBL113238 | 9.41 | Ki | 0.39 | Preclinical |
| CHEMBL7132 | 9.4 | Ki | 0.4 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 59 | 204 | 6.8 |
| assay format | 26 | 148 | 7.0 |
| cell-based format | 18 | 138 | 6.8 |
| tissue-based format | 18 | 70 | 7.5 |
| cell membrane format | 9 | 10 | 7.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 5 | 0 | — |
| assay format | 3 | 5 | 5.8 |
| cell-based format | 3 | 18 | 7.9 |
| tissue-based format | 3 | 30 | 6.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 5 | 7.4 |
| tissue-based format | 1 | 4 | 7.0 |