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Target Snapshot

CHEMBL3250 Target Snapshot

Lysophosphatidic acid receptor 3 · SINGLE PROTEIN · Homo sapiens

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321Compounds
70Assays
0Approved Drugs
369.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9UBY5. Use UniProt Q9UBY5 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9UBY5 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Lysophosphatidic acid receptor 3 as ChEMBL target CHEMBL3250, mapped to UniProt Q9UBY5. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Lysophosphatidic acid receptor 3
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3250
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9UBY5
Lysophosphatidic acid receptor 3
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Lysophosphatidic acid receptor 3 is the right protein anchor across sources, using UniProt Q9UBY5 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameLysophosphatidic acid receptor 3
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9UBY5
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLysophosphatidic acid receptor 3
UniProt AccessionQ9UBY5
Component TypeProtein
Sequence Length353 aa

Lysophosphatidic acid receptor 3

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Lysophosphatidic acid receptor 3, mapped to UniProt Q9UBY5. Sequence length is 353 aa.

Mapped IDQ9UBY5
Review nameLysophosphatidic acid receptor 3
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC50171.0
KI69.0
EC50129.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2335051 9.69 EC50 0.2042 Preclinical
CHEMBL2335052 9.65 EC50 0.2239 Preclinical
CHEMBL357053 9.57 EC50 0.2692 Preclinical
CHEMBL2017139 9.56 EC50 0.2754 Preclinical
CHEMBL2335049 9.44 EC50 0.36 Preclinical
CHEMBL2335047 9.43 EC50 0.37 Preclinical
CHEMBL2335050 9.41 EC50 0.39 Preclinical
CHEMBL153043 9.36 EC50 0.44 Preclinical
CHEMBL2335048 8.97 EC50 1.072 Preclinical
CHEMBL201482 8.52 EC50 3.0 Preclinical
Distribution

pChEMBL Value Distribution

28
5.0
42
5.5
40
6.0
44
6.5
22
7.0
13
7.5
1
8.0
3
8.5
8
9.0
8
9.5
pChEMBL
Assay Landscape

Assay Landscape

70
Total Assays
97
Tested Compounds
2
Assay Types
Functional — 52 assays, 91 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 46 80 6.1
assay format 3 1 6.6
single protein format 3 10 5.6
Binding — 18 assays, 97 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 9 71 7.1
single protein format 9 26 6.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine