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Target Snapshot

CHEMBL3257 Target Snapshot

Aldehyde oxidase · SINGLE PROTEIN · Homo sapiens

215Compounds
140Assays
20Approved Drugs
57.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q06278. Use UniProt Q06278 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q06278 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Aldehyde oxidase as ChEMBL target CHEMBL3257, mapped to UniProt Q06278. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Aldehyde oxidase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3257
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q06278
Aldehyde oxidase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Aldehyde oxidase is the right protein anchor across sources, using UniProt Q06278 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAldehyde oxidase
UniProt AccessionQ06278
Component TypeProtein
Sequence Length1338 aa

Aldehyde oxidase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Aldehyde oxidase, mapped to UniProt Q06278. Sequence length is 1338 aa.

Mapped IDQ06278
Review nameAldehyde oxidase
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

20
Approved
2
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC5027.0
KI30.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL81 9.06 Ki 0.87 Approved
CHEMBL81 8.52 IC50 3.0 Approved
CHEMBL44 8.3 IC50 5.0 Clinical
CHEMBL135 8.3 IC50 5.0 Approved
CHEMBL691 8.3 IC50 5.0 Approved
CHEMBL567 7.48 IC50 33.0 Approved
CHEMBL56149 7.4 IC50 40.0 Preclinical
CHEMBL590 6.7 IC50 200.0 Approved
CHEMBL691 6.37 Ki 430.0 Approved
CHEMBL411 6.34 IC50 460.0 Approved
Distribution

pChEMBL Value Distribution

5
5.0
4
5.5
8
6.0
1
6.5
4
7.0
0
7.5
5
8.0
2
8.5
5
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

RALOXIFENE
CHEMBL81
Approved 1997
ETHINYL ESTRADIOL
CHEMBL691
Approved 1982
MENADIONE
CHEMBL590
Approved 1982
ESTRADIOL
CHEMBL135
Approved 1975
DIETHYLSTILBESTROL
CHEMBL411
Approved 1973
PERPHENAZINE
CHEMBL567
Approved 1957
CHLORPROMAZINE
CHEMBL71
Approved 1957
Assay Landscape

Assay Landscape

153
Total Assays
21
Tested Compounds
2
Assay Types
ADME — 141 assays, 21 compounds
BAO Format Assays Compounds Avg pChEMBL
subcellular format 54 0
cell-based format 34 0
assay format 25 1 4.1
tissue-based format 15 7 6.4
single protein format 12 13 6.7
organism-based format 1 0
Binding — 12 assays, 18 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 9 1 8.9
assay format 2 11 6.7
subcellular format 1 6 4.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine