Tyrosine-protein kinase BTK · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt P35991. Use UniProt P35991 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P35991 as the stable identity anchor, then attach disease evidence before program review.
Tyrosine-protein kinase BTK
Review this target as Tyrosine-protein kinase BTK, mapped to UniProt P35991. Sequence length is 659 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tyrosine-protein kinase BTK as ChEMBL target CHEMBL3259478, mapped to UniProt P35991. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Tyrosine-protein kinase BTK |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P35991 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein kinase BTK |
| UniProt Accession | P35991 |
| Component Type | Protein |
| Sequence Length | 659 aa |
Tyrosine-protein kinase BTK
Review this target as Tyrosine-protein kinase BTK, mapped to UniProt P35991. Sequence length is 659 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3928203 | 8.26 | IC50 | 5.5 | Preclinical |
| CHEMBL3936823 | 8.24 | IC50 | 5.8 | Preclinical |
| CHEMBL3670139 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL4852459 | 8.12 | IC50 | 7.6 | Preclinical |
| CHEMBL4846828 | 8.1 | IC50 | 7.9 | Preclinical |
| CHEMBL3959033 | 8.08 | IC50 | 8.3 | Preclinical |
| CHEMBL3967108 | 8.08 | IC50 | 8.4 | Preclinical |
| CHEMBL3670095 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL4851021 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL4875401 | 7.89 | IC50 | 13.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 28 | 1 | 6.9 |
| cell-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 5 | 14 | 7.1 |
| cell-based format | 4 | 32 | 6.4 |
| single protein format | 4 | 17 | 7.4 |
| organism-based format | 2 | 0 | — |
| assay format | 1 | 18 | 6.9 |