Lanosterol synthase · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P48450. Use UniProt P48450 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P48450 as the stable identity anchor, then attach disease evidence before program review.
Lanosterol synthase
Review this target as Lanosterol synthase, mapped to UniProt P48450. Sequence length is 733 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Lanosterol synthase as ChEMBL target CHEMBL3262, mapped to UniProt P48450. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Lanosterol synthase is the right protein anchor across sources, using UniProt P48450 as the stable mapping.
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| Preferred Name | Lanosterol synthase |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P48450 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Lanosterol synthase |
| UniProt Accession | P48450 |
| Component Type | Protein |
| Sequence Length | 733 aa |
Lanosterol synthase
Review this target as Lanosterol synthase, mapped to UniProt P48450. Sequence length is 733 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL17168 | 7.55 | Ki | 28.0 | Preclinical |
| CHEMBL64905 | 7.43 | Ki | 37.0 | Preclinical |
| CHEMBL135109 | 7.31 | IC50 | 49.0 | Preclinical |
| CHEMBL253784 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL253785 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL64905 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL25405 | 7.24 | IC50 | 58.0 | Preclinical |
| CHEMBL148268 | 7.09 | IC50 | 82.0 | Preclinical |
| CHEMBL25285 | 7.05 | IC50 | 90.0 | Preclinical |
| CHEMBL17168 | 7.0 | IC50 | 100.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 37 | 53 | 5.8 |
| microsome format | 5 | 4 | 5.4 |
| single protein format | 4 | 6 | 6.9 |
| tissue-based format | 1 | 15 | 5.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 0 | — |
| organism-based format | 2 | 0 | — |