Histamine H3 receptor · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt P58406. Use UniProt P58406 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P58406 as the stable identity anchor, then attach disease evidence before program review.
Histamine H3 receptor
Review this target as Histamine H3 receptor, mapped to UniProt P58406. Sequence length is 445 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histamine H3 receptor as ChEMBL target CHEMBL3263, mapped to UniProt P58406. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Histamine H3 receptor is the right protein anchor across sources, using UniProt P58406 as the stable mapping.
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| Preferred Name | Histamine H3 receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P58406 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histamine H3 receptor |
| UniProt Accession | P58406 |
| Component Type | Protein |
| Sequence Length | 445 aa |
Histamine H3 receptor
Review this target as Histamine H3 receptor, mapped to UniProt P58406. Sequence length is 445 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4441731 | 10.0 | EC50 | 0.1 | Preclinical |
| CHEMBL1824230 | 9.55 | Ki | 0.28 | Preclinical |
| CHEMBL1824235 | 9.48 | Ki | 0.33 | Preclinical |
| CHEMBL1824231 | 9.28 | Ki | 0.52 | Preclinical |
| CHEMBL14690 | 9.22 | Ki | 0.6 | Preclinical |
| CHEMBL14690 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL1824234 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL1824236 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL4441731 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL1824245 | 8.85 | Ki | 1.4 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 16 | 0 | — |
| assay format | 3 | 1 | 10.0 |
| cell-based format | 3 | 15 | 6.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 7 | 49 | 7.8 |
| cell-based format | 4 | 9 | 8.4 |
| organism-based format | 4 | 0 | — |
| assay format | 3 | 7 | 7.4 |
| tissue-based format | 2 | 17 | 8.7 |
| cell membrane format | 1 | 1 | 8.5 |