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Target Snapshot

CHEMBL3266 Target Snapshot

Retinoic acid receptor beta · SINGLE PROTEIN · Mus musculus

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75Compounds
15Assays
4Approved Drugs
53.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P22605. Use UniProt P22605 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P22605 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Retinoic acid receptor beta as ChEMBL target CHEMBL3266, mapped to UniProt P22605. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Retinoic acid receptor beta
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL3266
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P22605
Retinoic acid receptor beta
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Retinoic acid receptor beta is the right protein anchor across sources, using UniProt P22605 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameRetinoic acid receptor beta
Target TypeSINGLE PROTEIN
OrganismMus musculus
UniProtP22605
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelRetinoic acid receptor beta
UniProt AccessionP22605
Component TypeProtein
Sequence Length482 aa

Retinoic acid receptor beta

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Retinoic acid receptor beta, mapped to UniProt P22605. Sequence length is 482 aa.

Mapped IDP22605
Review nameRetinoic acid receptor beta
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

4
Approved
Assay Mix

Activity Type Distribution

IC5016.0
EC5029.0
KD8.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL38 9.28 EC50 0.52 Approved
CHEMBL345298 9.08 EC50 0.83 Preclinical
CHEMBL4572914 8.85 EC50 1.4 Preclinical
CHEMBL4588745 8.82 EC50 1.5 Preclinical
CHEMBL4459692 8.72 EC50 1.9 Preclinical
CHEMBL4449668 8.66 EC50 2.2 Preclinical
CHEMBL4439399 8.6 EC50 2.5 Preclinical
CHEMBL4438880 8.47 EC50 3.4 Preclinical
CHEMBL38 8.3 IC50 5.0 Approved
CHEMBL46398 8.22 IC50 6.0 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
3
5.5
5
6.0
4
6.5
3
7.0
8
7.5
8
8.0
7
8.5
2
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ALITRETINOIN
CHEMBL705
Approved 1999
Properties Compare Identifier
TRETINOIN
CHEMBL38
Approved 1971
Properties Compare Identifier
Assay Landscape

Assay Landscape

15
Total Assays
40
Tested Compounds
2
Assay Types
Binding — 14 assays, 40 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 10 26 7.7
single protein format 4 14 6.9
Functional — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine