Cathepsin L2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt O60911. Use UniProt O60911 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O60911 as the stable identity anchor, then attach disease evidence before program review.
Cathepsin L2
Review this target as Cathepsin L2, mapped to UniProt O60911. Sequence length is 334 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cathepsin L2 as ChEMBL target CHEMBL3272, mapped to UniProt O60911. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Cathepsin L2 is the right protein anchor across sources, using UniProt O60911 as the stable mapping.
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| Preferred Name | Cathepsin L2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O60911 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cathepsin L2 |
| UniProt Accession | O60911 |
| Component Type | Protein |
| Sequence Length | 334 aa |
Cathepsin L2
Review this target as Cathepsin L2, mapped to UniProt O60911. Sequence length is 334 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL203665 | 10.2 | Ki | 0.063 | Clinical |
| CHEMBL286364 | 8.74 | Ki | 1.8 | Preclinical |
| CHEMBL554065 | 8.7 | IC50 | 1.995 | Preclinical |
| CHEMBL562844 | 8.5 | IC50 | 3.162 | Preclinical |
| CHEMBL549378 | 8.2 | IC50 | 6.31 | Preclinical |
| CHEMBL550872 | 8.2 | IC50 | 6.31 | Preclinical |
| CHEMBL549791 | 8.1 | IC50 | 7.943 | Preclinical |
| CHEMBL1289645 | 7.78 | IC50 | 16.6 | Preclinical |
| CHEMBL562915 | 7.7 | IC50 | 19.95 | Preclinical |
| CHEMBL559880 | 7.6 | IC50 | 25.12 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 34 | 110 | 6.3 |
| assay format | 6 | 40 | 5.4 |