NAD-dependent histone deacetylase SIR2 · SINGLE PROTEIN · Saccharomyces cerevisiae S288c
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P06700. Use UniProt P06700 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P06700 as the stable identity anchor, then attach disease evidence before program review.
NAD-dependent histone deacetylase SIR2
Review this target as NAD-dependent histone deacetylase SIR2, mapped to UniProt P06700. Sequence length is 562 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats NAD-dependent histone deacetylase SIR2 as ChEMBL target CHEMBL3275, mapped to UniProt P06700. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether NAD-dependent histone deacetylase SIR2 is the right protein anchor across sources, using UniProt P06700 as the stable mapping.
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| Preferred Name | NAD-dependent histone deacetylase SIR2 |
| Target Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
| UniProt | P06700 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | NAD-dependent histone deacetylase SIR2 |
| UniProt Accession | P06700 |
| Component Type | Protein |
| Sequence Length | 562 aa |
NAD-dependent histone deacetylase SIR2
Review this target as NAD-dependent histone deacetylase SIR2, mapped to UniProt P06700. Sequence length is 562 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL316059 | 5.06 | IC50 | 8800.0 | Preclinical |
| CHEMBL313393 | 4.92 | IC50 | 12000.0 | Preclinical |
| CHEMBL314311 | 4.6 | IC50 | 25000.0 | Preclinical |
| CHEMBL313293 | 4.57 | IC50 | 27000.0 | Preclinical |
| CHEMBL88683 | 4.57 | IC50 | 27000.0 | Preclinical |
| CHEMBL91134 | 4.57 | IC50 | 27000.0 | Preclinical |
| CHEMBL372375 | 4.48 | IC50 | 33000.0 | Preclinical |
| CHEMBL88830 | 4.41 | IC50 | 39000.0 | Preclinical |
| CHEMBL327644 | 4.39 | IC50 | 41000.0 | Preclinical |
| CHEMBL315508 | 4.37 | IC50 | 43000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 26 | 33 | 4.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 0 | — |