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Target Snapshot

CHEMBL3288 Target Snapshot

Ryanodine receptor 1 · SINGLE PROTEIN · Oryctolagus cuniculus

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91Compounds
11Assays
0Approved Drugs
41.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P11716. Use UniProt P11716 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P11716 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Ryanodine receptor 1 as ChEMBL target CHEMBL3288, mapped to UniProt P11716. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Ryanodine receptor 1
SINGLE PROTEIN · Oryctolagus cuniculus
As of 2026-09-14
ChEMBL target ID
CHEMBL3288
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P11716
Ryanodine receptor 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Choose the first block or source based on the question you are trying to answer.

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Ryanodine receptor 1 is the right protein anchor across sources, using UniProt P11716 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameRyanodine receptor 1
Target TypeSINGLE PROTEIN
OrganismOryctolagus cuniculus
UniProtP11716
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelRyanodine receptor 1
UniProt AccessionP11716
Component TypeProtein
Sequence Length5037 aa

Ryanodine receptor 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Ryanodine receptor 1, mapped to UniProt P11716. Sequence length is 5037 aa.

Mapped IDP11716
Review nameRyanodine receptor 1
OrganismOryctolagus cuniculus
Assay Mix

Activity Type Distribution

IC5036.0
EC505.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL27669 8.96 IC50 1.1 Preclinical
CHEMBL283836 8.74 IC50 1.8 Preclinical
CHEMBL435362 8.74 IC50 1.8 Preclinical
CHEMBL2112186 8.7 IC50 2.0 Preclinical
CHEMBL282089 8.59 IC50 2.6 Preclinical
CHEMBL28383 8.32 IC50 4.8 Preclinical
CHEMBL435162 8.23 IC50 5.9 Preclinical
CHEMBL283783 8.05 IC50 8.9 Preclinical
CHEMBL2273036 7.89 IC50 13.0 Preclinical
CHEMBL2273038 7.39 IC50 41.0 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
2
5.5
1
6.0
6
6.5
5
7.0
1
7.5
6
8.0
5
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

11
Total Assays
32
Tested Compounds
3
Assay Types
Binding — 9 assays, 32 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 8 20 6.3
assay format 1 12 8.0
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 0 —
Functional — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine