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Target Snapshot

CHEMBL3297639 Target Snapshot

G-protein coupled receptor 52 · SINGLE PROTEIN · Homo sapiens

373Compounds
34Assays
0Approved Drugs
396.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9Y2T5. Use UniProt Q9Y2T5 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9Y2T5 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats G-protein coupled receptor 52 as ChEMBL target CHEMBL3297639, mapped to UniProt Q9Y2T5. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
G-protein coupled receptor 52
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3297639
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9Y2T5
G-protein coupled receptor 52
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether G-protein coupled receptor 52 is the right protein anchor across sources, using UniProt Q9Y2T5 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelG-protein coupled receptor 52
UniProt AccessionQ9Y2T5
Component TypeProtein
Sequence Length361 aa

G-protein coupled receptor 52

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as G-protein coupled receptor 52, mapped to UniProt Q9Y2T5. Sequence length is 361 aa.

Mapped IDQ9Y2T5
Review nameG-protein coupled receptor 52
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5033.0
EC50363.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4852000 8.97 EC50 1.06 Preclinical
CHEMBL4845846 8.96 EC50 1.1 Preclinical
CHEMBL4846330 8.96 EC50 1.1 Preclinical
CHEMBL4846333 8.96 EC50 1.1 Preclinical
CHEMBL4846416 8.96 EC50 1.1 Preclinical
CHEMBL4846586 8.96 EC50 1.1 Preclinical
CHEMBL4846775 8.96 EC50 1.1 Preclinical
CHEMBL4846914 8.96 EC50 1.1 Preclinical
CHEMBL4846977 8.96 EC50 1.1 Preclinical
CHEMBL4847685 8.96 EC50 1.1 Preclinical
Distribution

pChEMBL Value Distribution

9
5.0
25
5.5
50
6.0
42
6.5
47
7.0
39
7.5
15
8.0
160
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

34
Total Assays
346
Tested Compounds
2
Assay Types
Functional — 26 assays, 346 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 24 345 7.8
assay format 2 1 7.0
Binding — 8 assays, 24 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 7 7 6.0
cell-based format 1 17 7.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine