Programmed cell death protein 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Programmed cell death protein 1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 22 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q15116. Start with neoplasm, then reuse UniProt Q15116 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt Q15116 as the stable protein anchor across project notes and exports.
Programmed cell death protein 1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 22 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include BALSTILIMAB, BUDIGALIMAB, CADONILIMAB, CAMRELIZUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyProgrammed cell death protein 1
Review this target as Programmed cell death protein 1, mapped to UniProt Q15116. Sequence length is 288 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Programmed cell death protein 1 as ChEMBL target CHEMBL3307223, mapped to UniProt Q15116. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Programmed cell death protein 1 is the right protein anchor across sources, using UniProt Q15116 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 22 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Programmed cell death protein 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q15116 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Programmed cell death protein 1 |
| UniProt Accession | Q15116 |
| Component Type | Protein |
| Sequence Length | 288 aa |
Programmed cell death protein 1
Review this target as Programmed cell death protein 1, mapped to UniProt Q15116. Sequence length is 288 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Programmed cell death protein 1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include BALSTILIMAB, BUDIGALIMAB, CADONILIMAB, CAMRELIZUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5572472 | 8.51 | IC50 | 3.1 | Preclinical |
| CHEMBL5092744 | 8.48 | Kd | 3.34 | Preclinical |
| CHEMBL4583803 | 5.86 | Kd | 1380.0 | Preclinical |
| CHEMBL4458745 | 5.5 | Kd | 3140.0 | Preclinical |
| CHEMBL4544177 | 5.5 | Kd | 3130.0 | Preclinical |
| CHEMBL4436009 | 5.47 | Kd | 3390.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 8 | 3 | 8.5 |
| assay format | 1 | 4 | 5.6 |
| cell-based format | 1 | 0 | — |