Platelet glycoprotein VI · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Platelet glycoprotein VI shows clinical signal disease relevance led by stroke. 3 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q9HCN6. Start with stroke, then reuse UniProt Q9HCN6 as the stable protein anchor across project notes and exports.
Start with stroke, then reuse UniProt Q9HCN6 as the stable protein anchor across project notes and exports.
Platelet glycoprotein VI shows clinical signal disease relevance led by stroke. 3 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with stroke because it currently carries clinical signal support. Linked drugs include GLENZOCIMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyPlatelet glycoprotein VI
Review this target as Platelet glycoprotein VI, mapped to UniProt Q9HCN6. Sequence length is 339 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Platelet glycoprotein VI as ChEMBL target CHEMBL3308912, mapped to UniProt Q9HCN6. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Platelet glycoprotein VI is the right protein anchor across sources, using UniProt Q9HCN6 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why stroke is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Platelet glycoprotein VI |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9HCN6 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Platelet glycoprotein VI |
| UniProt Accession | Q9HCN6 |
| Component Type | Protein |
| Sequence Length | 339 aa |
Platelet glycoprotein VI
Review this target as Platelet glycoprotein VI, mapped to UniProt Q9HCN6. Sequence length is 339 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Platelet glycoprotein VI shows clinical signal disease relevance led by stroke. 3 more disease programs remain visible in the same review block.
Start review with stroke because it currently carries clinical signal support. Linked drugs include GLENZOCIMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL549359 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL1235110 | 7.51 | IC50 | 31.0 | Preclinical |
| CHEMBL96 | 7.39 | Kd | 41.1 | Preclinical |
| CHEMBL1873475 | 6.92 | IC50 | 120.0 | Approved |
| CHEMBL3936761 | 6.29 | IC50 | 510.0 | Approved |
| CHEMBL3707348 | 5.92 | IC50 | 1210.0 | Approved |
| CHEMBL4071161 | 5.92 | IC50 | 1200.0 | Approved |
| CHEMBL191 | 5.4 | IC50 | 4000.0 | Approved |
| CHEMBL3959435 | 5.24 | IC50 | 5700.0 | Preclinical |
| CHEMBL4072833 | 5.23 | IC50 | 5840.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-free format | 18 | 6 | 4.7 |
| tissue-based format | 8 | 9 | 6.2 |
| subcellular format | 3 | 2 | 7.4 |
| single protein format | 2 | 13 | 4.2 |
| assay format | 1 | 1 | — |