Lys-gingipain · SINGLE PROTEIN · Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257)
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As of 2026-09-14Protein identity stays anchored to UniProt B2RLK2. Use UniProt B2RLK2 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt B2RLK2 as the stable identity anchor, then attach disease evidence before program review.
Lys-gingipain
Review this target as Lys-gingipain, mapped to UniProt B2RLK2. Sequence length is 1723 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Lys-gingipain as ChEMBL target CHEMBL3308977, mapped to UniProt B2RLK2. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Lys-gingipain |
| Target Type | SINGLE PROTEIN |
| Organism | Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) |
| UniProt | B2RLK2 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Lys-gingipain |
| UniProt Accession | B2RLK2 |
| Component Type | Protein |
| Sequence Length | 1723 aa |
Lys-gingipain
Review this target as Lys-gingipain, mapped to UniProt B2RLK2. Sequence length is 1723 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5751174 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL5944096 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL6004445 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL5847329 | 10.15 | IC50 | 0.07 | Preclinical |
| CHEMBL5860406 | 10.15 | IC50 | 0.07 | Preclinical |
| CHEMBL5772373 | 10.1 | IC50 | 0.08 | Preclinical |
| CHEMBL5819238 | 10.1 | IC50 | 0.08 | Preclinical |
| CHEMBL5898122 | 10.1 | IC50 | 0.08 | Preclinical |
| CHEMBL5814292 | 10.05 | IC50 | 0.09 | Preclinical |
| CHEMBL5886870 | 10.05 | IC50 | 0.09 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 3 | 85 | 8.6 |