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Target Snapshot

CHEMBL3309112 Target Snapshot

Bcl-2-like protein 1 · SINGLE PROTEIN · Mus musculus

594Compounds
5Assays
0Approved Drugs
598.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q64373. Use UniProt Q64373 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q64373 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Bcl-2-like protein 1 as ChEMBL target CHEMBL3309112, mapped to UniProt Q64373. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Bcl-2-like protein 1
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL3309112
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q64373
Bcl-2-like protein 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Bcl-2-like protein 1 is the right protein anchor across sources, using UniProt Q64373 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBcl-2-like protein 1
UniProt AccessionQ64373
Component TypeProtein
Sequence Length233 aa

Bcl-2-like protein 1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Bcl-2-like protein 1, mapped to UniProt Q64373. Sequence length is 233 aa.

Mapped IDQ64373
Review nameBcl-2-like protein 1
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Phase I
Assay Mix

Activity Type Distribution

KI424.0
EC50172.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL376408 10.1 Ki 0.08 Preclinical
CHEMBL3964488 10.0 EC50 0.1 Preclinical
CHEMBL3945285 9.7 EC50 0.2 Preclinical
CHEMBL3978558 9.7 EC50 0.2 Preclinical
CHEMBL3920580 9.55 Ki 0.281 Preclinical
CHEMBL3945287 9.52 EC50 0.3 Preclinical
CHEMBL3946776 9.46 Ki 0.345 Preclinical
CHEMBL3933468 9.41 Ki 0.388 Preclinical
CHEMBL3969380 9.38 Ki 0.412 Preclinical
CHEMBL3930283 9.3 EC50 0.5 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
1
5.5
54
6.0
75
6.5
79
7.0
75
7.5
61
8.0
10
8.5
14
9.0
4
9.5
pChEMBL
Assay Landscape

Assay Landscape

5
Total Assays
378
Tested Compounds
1
Assay Types
Binding — 5 assays, 378 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 259 7.5
cell-based format 1 119 7.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine